The sterol-sensing domain: multiple families, a unique role?
PE Kuwabara, M Labouesse - Trends in genetics, 2002 - cell.com
PE Kuwabara, M Labouesse
Trends in genetics, 2002•cell.comAbstract The 'sterol-sensing domain'(SSD) is conserved across phyla and is present in
several membrane proteins, such as Patched (a Hedgehog receptor) and NPC-1 (the
protein defective in Niemann–Pick type C1 disease). The role of the SSD is perhaps best
understood from the standpoint of its involvement in cholesterol homeostasis. This article
discusses how the SSD appears to function as a regulatory domain involved in linking
vesicle trafficking and protein localization with such varied processes as cholesterol …
several membrane proteins, such as Patched (a Hedgehog receptor) and NPC-1 (the
protein defective in Niemann–Pick type C1 disease). The role of the SSD is perhaps best
understood from the standpoint of its involvement in cholesterol homeostasis. This article
discusses how the SSD appears to function as a regulatory domain involved in linking
vesicle trafficking and protein localization with such varied processes as cholesterol …
Abstract
The ‘sterol-sensing domain' (SSD) is conserved across phyla and is present in several membrane proteins, such as Patched (a Hedgehog receptor) and NPC-1 (the protein defective in Niemann–Pick type C1 disease). The role of the SSD is perhaps best understood from the standpoint of its involvement in cholesterol homeostasis. This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis.
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