A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus
Y Tada, K Nagasawa, Y Yamauchi… - Clinical immunology and …, 1991 - Elsevier
To determine whether there is an intrinsic defect in T cells from patients with systemic lupus
erythematosus (SLE), we studied signal transduction systems, assaying the total protein
kinase C (PKC) levels and the phorbol myristate acetate (PMA)-induced activation of PKC in
PHA-treated T cells. T cells from SLE patients showed a decrease in proliferation in
response to PMA, but not to PHA, thereby suggesting the existence of an intrinsic
abnormality in the PKC-mediated activation pathway. Total PKC activity in the T cells from …
erythematosus (SLE), we studied signal transduction systems, assaying the total protein
kinase C (PKC) levels and the phorbol myristate acetate (PMA)-induced activation of PKC in
PHA-treated T cells. T cells from SLE patients showed a decrease in proliferation in
response to PMA, but not to PHA, thereby suggesting the existence of an intrinsic
abnormality in the PKC-mediated activation pathway. Total PKC activity in the T cells from …
