[CITATION][C] Pathogenetic significance of anti-lymphocyte autoantibodies in systemic lupus erythematosus
JB Winfield, T Mimura - Clinical immunology and immunopathology, 1992 - Elsevier
Anti-lymphocyte autoantibodies in systemic lupus erythematosus (SLE), which vary in titer
with disease activity status in the same fashion as anti-dsDNA autoantib~ ies, are associated
with the depletion of circulating T cells and have the capacity for direct actions on target
cells, including complement-dependent cytotoxicity and ADCC, modulation of surface
antigens, and up-or doe-re~ lation of various cell functions in the immune response.
Although complete information concerning the molecules with which anti-lymphocyte …
with disease activity status in the same fashion as anti-dsDNA autoantib~ ies, are associated
with the depletion of circulating T cells and have the capacity for direct actions on target
cells, including complement-dependent cytotoxicity and ADCC, modulation of surface
antigens, and up-or doe-re~ lation of various cell functions in the immune response.
Although complete information concerning the molecules with which anti-lymphocyte …
