Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats
TV Arumugam, TM Woodruff, SZ Stocks, LM Proctor… - Journal of …, 2004 - Elsevier
BACKGROUND/AIMS: Complement activation is induced by ischaemia-reperfusion (I/R) and
the complement factor C5a plays an important role in organ specific I/R injuries. This study
investigated the efficacy of a small molecule C5a receptor (C5aR) antagonist against
hepatic I/R injury. METHODS: Total hepatic ischaemia or partial hepatic ischaemia were
induced in rats, followed by a period of reperfusion. The C5aR antagonist, AcF-
[OPdChaWR], was administered at 1 mg/kg iv or 10 mg/kg po or sc before induction of …
the complement factor C5a plays an important role in organ specific I/R injuries. This study
investigated the efficacy of a small molecule C5a receptor (C5aR) antagonist against
hepatic I/R injury. METHODS: Total hepatic ischaemia or partial hepatic ischaemia were
induced in rats, followed by a period of reperfusion. The C5aR antagonist, AcF-
[OPdChaWR], was administered at 1 mg/kg iv or 10 mg/kg po or sc before induction of …
