Antiinflammatory effects of soluble complement receptor type 1 promote rapid recovery of ischemia/reperfusion injury in rat small intestine
AT Eror, A Stojadinovic, BW Starnes, SC Makrides… - Clinical …, 1999 - Elsevier
We examined the effect of soluble complement receptor type 1 (sCR1) on mucosal injury
and inflammation in a rat model of ischemia/reperfusion. Groups of vehicle-and sCR1-
treated rats underwent 30 min of mesenteric ischemia followed by 60 or 120 min of
reperfusion. When compared to vehicle-treated rats, treatment with sCR1 (12 mg/kg) prior to
120 min of reperfusion significantly reduced mucosal injury, neutrophil infiltration,
leukotriene B4production, and restored villus height to control levels. The protective effect of …
and inflammation in a rat model of ischemia/reperfusion. Groups of vehicle-and sCR1-
treated rats underwent 30 min of mesenteric ischemia followed by 60 or 120 min of
reperfusion. When compared to vehicle-treated rats, treatment with sCR1 (12 mg/kg) prior to
120 min of reperfusion significantly reduced mucosal injury, neutrophil infiltration,
leukotriene B4production, and restored villus height to control levels. The protective effect of …
