C5 is required for CD49d expression on neutrophils and VCAM expression on vascular endothelial cells following mesenteric ischemia/reperfusion
SD Fleming, J Anderson, F Wilson, T Shea-Donohue… - Clinical …, 2003 - Elsevier
Complement activation is critical in the development of local mucosal damage and
inflammation as well as of remote organ injury after mesenteric ischemia/reperfusion. To
further define the role of C5 activation in local and remote tissue injury, C5 deficient (C5−/−)
and wild-type control (C5+/+) mice treated with an anti-C5 mAb were subjected to sham or
ischemia followed by up to 4 h of reperfusion. The development of local (intestinal) and
remote (lung) injury was associated with the expression of CD49d on the surface of …
inflammation as well as of remote organ injury after mesenteric ischemia/reperfusion. To
further define the role of C5 activation in local and remote tissue injury, C5 deficient (C5−/−)
and wild-type control (C5+/+) mice treated with an anti-C5 mAb were subjected to sham or
ischemia followed by up to 4 h of reperfusion. The development of local (intestinal) and
remote (lung) injury was associated with the expression of CD49d on the surface of …
