Antiretroviral drugs and the central nervous system
RH Enting, RMW Hoetelmans, JMA Lange, DM Burger… - Aids, 1998 - journals.lww.com
RH Enting, RMW Hoetelmans, JMA Lange, DM Burger, JH Beijnen, P Portegies
Aids, 1998•journals.lww.comWith potent antiretroviral drug combinations it is possible to reduce the number of HIV RNA
copies in plasma to undetectable levels [1]. Persistent low levels of HIV RNA in plasma are
correlated with an improved prognosis [2]. However, for several sites in the infected host, it is
as yet unclear how efficacious combination treatment is in suppressing viral replication. One
of these sanctuary sites is the central nervous system (CNS).The presence of HIV and the
level of HIV replication in the brain parenchyma are difficult to study, and we have to rely on …
copies in plasma to undetectable levels [1]. Persistent low levels of HIV RNA in plasma are
correlated with an improved prognosis [2]. However, for several sites in the infected host, it is
as yet unclear how efficacious combination treatment is in suppressing viral replication. One
of these sanctuary sites is the central nervous system (CNS).The presence of HIV and the
level of HIV replication in the brain parenchyma are difficult to study, and we have to rely on …
With potent antiretroviral drug combinations it is possible to reduce the number of HIV RNA copies in plasma to undetectable levels [1]. Persistent low levels of HIV RNA in plasma are correlated with an improved prognosis [2]. However, for several sites in the infected host, it is as yet unclear how efficacious combination treatment is in suppressing viral replication. One of these sanctuary sites is the central nervous system (CNS).
The presence of HIV and the level of HIV replication in the brain parenchyma are difficult to study, and we have to rely on post-mortem examination of brain tissue, animal studies, and cerebrospinal fluid (CSF) levels of HIV RNA. For clinical practice, CSF viral load measurements are relatively easy to obtain and are potentially useful.
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