Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling
E Gluckman, HE Broxmeyer… - … England Journal of …, 1989 - Mass Medical Soc
E Gluckman, HE Broxmeyer, AD Auerbach, HS Friedman, GW Douglas, A Devergie…
New England Journal of Medicine, 1989•Mass Medical SocTHE clinical manifestations of Fanconi's anemia, an autosomal recessive disorder, include
progressive pancytopenia, a predisposition to neoplasia, and nonhematopoietic
developmental anomalies. 1 2 3 Hypersensitivity to the clastogenic effect of DNA–cross-
linking agents such as diepoxybutane acts as a diagnostic indicator of the genotype of
Fanconi's anemia, both prenatally and postnatally. 3 4 5 6 Prenatal HLA typing has made it
possible to ascertain whether a fetus is HLA-identical to an affected sibling. 7 We report here …
progressive pancytopenia, a predisposition to neoplasia, and nonhematopoietic
developmental anomalies. 1 2 3 Hypersensitivity to the clastogenic effect of DNA–cross-
linking agents such as diepoxybutane acts as a diagnostic indicator of the genotype of
Fanconi's anemia, both prenatally and postnatally. 3 4 5 6 Prenatal HLA typing has made it
possible to ascertain whether a fetus is HLA-identical to an affected sibling. 7 We report here …
THE clinical manifestations of Fanconi's anemia, an autosomal recessive disorder, include progressive pancytopenia, a predisposition to neoplasia, and nonhematopoietic developmental anomalies.1 2 3 Hypersensitivity to the clastogenic effect of DNA–cross-linking agents such as diepoxybutane acts as a diagnostic indicator of the genotype of Fanconi's anemia, both prenatally and postnatally.3 4 5 6 Prenatal HLA typing has made it possible to ascertain whether a fetus is HLA-identical to an affected sibling.7
We report here on hematopoietic reconstitution in a boy with severe Fanconi's anemia who received cryopreserved umbilical-cord blood from a sister shown by prenatal testing to be unaffected by the disorder, to have a normal . . .
The New England Journal Of Medicine