Heat shock protein 90
L Neckers, SP Ivy - Current opinion in oncology, 2003 - journals.lww.com
L Neckers, SP Ivy
Current opinion in oncology, 2003•journals.lww.comHsp90 inhibitors may circumvent the characteristic genetic plasticity that has allowed cancer
cells to eventually evade the toxic effects of most molecularly targeted agents. The
mechanism-based use of Hsp90 inhibitors, both alone and in combination with other drugs,
should augment the treatment of multiple forms of cancer.
cells to eventually evade the toxic effects of most molecularly targeted agents. The
mechanism-based use of Hsp90 inhibitors, both alone and in combination with other drugs,
should augment the treatment of multiple forms of cancer.
Summary
Hsp90 inhibitors may circumvent the characteristic genetic plasticity that has allowed cancer cells to eventually evade the toxic effects of most molecularly targeted agents. The mechanism-based use of Hsp90 inhibitors, both alone and in combination with other drugs, should augment the treatment of multiple forms of cancer.
Lippincott Williams & Wilkins