[HTML][HTML] The role of c-FLIP in modulation of CD95-induced apoptosis
C Scaffidi, I Schmitz, PH Krammer, ME Peter - Journal of Biological …, 1999 - ASBMB
Upon stimulation, CD95 (APO-1/Fas) recruits the adapter molecule Fas-associated death
domain protein (FADD)/MORT1 and caspase-8 (FADD-like interleukin-1β-converting
enzyme (FLICE)/MACH/MCH5) into the death-inducing signaling complex (DISC). Recently,
a molecule with sequence homology to caspase-8 was identified, termed cellular FLICE-
inhibitory protein (c-FLIP). c-FLIP has been controversially reported to possess apoptosis-
promoting and-inhibiting functions. Using c-FLIP-specific monoclonal antibodies, we now …
domain protein (FADD)/MORT1 and caspase-8 (FADD-like interleukin-1β-converting
enzyme (FLICE)/MACH/MCH5) into the death-inducing signaling complex (DISC). Recently,
a molecule with sequence homology to caspase-8 was identified, termed cellular FLICE-
inhibitory protein (c-FLIP). c-FLIP has been controversially reported to possess apoptosis-
promoting and-inhibiting functions. Using c-FLIP-specific monoclonal antibodies, we now …
