[HTML][HTML] Active Rho kinase (ROK-α) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells
N Begum, OA Sandu, M Ito, SM Lohmann… - Journal of Biological …, 2002 - ASBMB
Recent studies from our laboratory have shown that insulin stimulates myosin-bound
phosphatase (MBP) in vascular smooth muscle cells (VSMCs) by decreasing site-specific
phosphorylation of the myosin-bound subunit (MBS) of MBP via nitric oxide/cGMP-mediated
Rho/Rho kinase inactivation. Here we tested potential interactions between Rho kinase and
insulin signaling pathways. In control VSMCs, insulin inactivates ROK-α, the major Rho
kinase isoform in VSMCs, and inhibits thrombin-induced increase in ROK-α association with …
phosphatase (MBP) in vascular smooth muscle cells (VSMCs) by decreasing site-specific
phosphorylation of the myosin-bound subunit (MBS) of MBP via nitric oxide/cGMP-mediated
Rho/Rho kinase inactivation. Here we tested potential interactions between Rho kinase and
insulin signaling pathways. In control VSMCs, insulin inactivates ROK-α, the major Rho
kinase isoform in VSMCs, and inhibits thrombin-induced increase in ROK-α association with …
