Paxillin: adapting to change
MC Brown, CE Turner - Physiological reviews, 2004 - journals.physiology.org
MC Brown, CE Turner
Physiological reviews, 2004•journals.physiology.orgMolecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and
integration of multiple signaling pathways to effect the optimal cellular response to changes
in the immediate environment. Paxillin is a multidomain adaptor that recruits both structural
and signaling molecules to focal adhesions, sites of integrin engagement with the
extracellular matrix, where it performs a critical role in transducing adhesion and growth
factor signals to elicit changes in cell migration and gene expression.
integration of multiple signaling pathways to effect the optimal cellular response to changes
in the immediate environment. Paxillin is a multidomain adaptor that recruits both structural
and signaling molecules to focal adhesions, sites of integrin engagement with the
extracellular matrix, where it performs a critical role in transducing adhesion and growth
factor signals to elicit changes in cell migration and gene expression.
Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and integration of multiple signaling pathways to effect the optimal cellular response to changes in the immediate environment. Paxillin is a multidomain adaptor that recruits both structural and signaling molecules to focal adhesions, sites of integrin engagement with the extracellular matrix, where it performs a critical role in transducing adhesion and growth factor signals to elicit changes in cell migration and gene expression.
American Physiological Society