[HTML][HTML] JAK2/STAT3, not ERK1/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular …
XW Yu, RH Kennedy, SJ Liu - Journal of biological chemistry, 2003 - ASBMB
Interleukin (IL)-6 decreases cardiac contractility via a nitric oxide (NO)-dependent pathway.
However, mechanisms underlying IL-6-induced NO production remain unclear. JAK2/STAT3
and ERK1/2 are two well known signaling pathways activated by IL-6 in non-cardiac cells.
However, these IL-6-activated pathways have not been identified in adult cardiac myocytes.
In this study, we identified activation of these two pathways during IL-6 stimulation and
examined their roles in IL-6-induced NO production and decrease in contractility of adult …
However, mechanisms underlying IL-6-induced NO production remain unclear. JAK2/STAT3
and ERK1/2 are two well known signaling pathways activated by IL-6 in non-cardiac cells.
However, these IL-6-activated pathways have not been identified in adult cardiac myocytes.
In this study, we identified activation of these two pathways during IL-6 stimulation and
examined their roles in IL-6-induced NO production and decrease in contractility of adult …