Interleukin-6 expression and regulation in astrocytes
NJ Van Wagoner, EN Benveniste - Journal of neuroimmunology, 1999 - Elsevier
The physiological function of interleukin-6 (IL-6) within the central nervous system (CNS) is
complex; IL-6 exerts neurotrophic and neuroprotective effects, and yet can also function as a
mediator of inflammation, demyelination, and astrogliosis, depending on the cellular context.
In the normal brain, IL-6 levels remain low. However, elevated expression occurs in injury,
infection, stroke, and inflammation. Given the diverse biological functions of IL-6 and its
expression in numerous CNS conditions, it is critical to understand its regulation in the brain …
complex; IL-6 exerts neurotrophic and neuroprotective effects, and yet can also function as a
mediator of inflammation, demyelination, and astrogliosis, depending on the cellular context.
In the normal brain, IL-6 levels remain low. However, elevated expression occurs in injury,
infection, stroke, and inflammation. Given the diverse biological functions of IL-6 and its
expression in numerous CNS conditions, it is critical to understand its regulation in the brain …