Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids.
DB Jump, SD Clarke, A Thelen, M Liimatta - Journal of lipid research, 1994 - ASBMB
Using a combination of in vivo and in vitro studies, we have investigated the impact of
polyunsaturated fatty acids (PUFA) on the expression of several genes encoding proteins
involved in hepatic glycolysis and lipogenesis. Meal-training rats to a high glucose diet
containing 10% triolein led to a significant induction of hepatic mRNAs encoding
glucokinase (GK), pyruvate kinase (PK), fatty acid synthase (FAS), malic enzyme (ME), and
the S14 protein (S14), but had no effect on thyroid hormone receptor-beta 1 (TR beta 1) and …
polyunsaturated fatty acids (PUFA) on the expression of several genes encoding proteins
involved in hepatic glycolysis and lipogenesis. Meal-training rats to a high glucose diet
containing 10% triolein led to a significant induction of hepatic mRNAs encoding
glucokinase (GK), pyruvate kinase (PK), fatty acid synthase (FAS), malic enzyme (ME), and
the S14 protein (S14), but had no effect on thyroid hormone receptor-beta 1 (TR beta 1) and …