The Role of N-Glycosylation for Functional Expression of the Human Platelet-activating Factor Receptor: GLYCOSYLATION IS REQUIRED FOR EFFICIENT …
CG Rodríguez, DR Cundell, EI Tuomanen… - Journal of Biological …, 1995 - ASBMB
Streptococcus pneumoniae has been shown to utilize the platelet activating factor receptor
for binding and invasion of host cells (Cundell, DR, Gerard, NP, Gerard, C., Idanpaan-
Heikkila, I., and Tuomanen, EI (1995) Nature, in press). Because bacterial binding is in part
carbohydrate dependent, and the human platelet-activating factor (PAF) receptor bears a
single N-linked glycosylation sequence in the second extracellular loop, we undertook
studies to determine the role of this epitope in PAF receptor function. Binding of …
for binding and invasion of host cells (Cundell, DR, Gerard, NP, Gerard, C., Idanpaan-
Heikkila, I., and Tuomanen, EI (1995) Nature, in press). Because bacterial binding is in part
carbohydrate dependent, and the human platelet-activating factor (PAF) receptor bears a
single N-linked glycosylation sequence in the second extracellular loop, we undertook
studies to determine the role of this epitope in PAF receptor function. Binding of …
