Identification and pharmacological characterization of platelet-activating factor and related 1-palmitoyl species in human inflammatory blistering diseases
JB Travers, RC Murphy, CA Johnson, Y Pei… - Prostaglandins & other …, 1998 - Elsevier
Through its pro-inflammatory effects on leukocytes, endothelial cells, and keratinocytes, the
lipid mediator platelet-activating factor (PAF) has been implicated in cutaneous
inflammation. Although the 1-alkyl PAF species has been considered historically the most
abundant and important ligand for the PAF receptor (PAF-R), other putative ligands for this
receptor have been described including 1-acyl analogs of sn-2 acetyl
glycerophosphocholines. Previous bioassays have demonstrated a PAF-like activity in …
lipid mediator platelet-activating factor (PAF) has been implicated in cutaneous
inflammation. Although the 1-alkyl PAF species has been considered historically the most
abundant and important ligand for the PAF receptor (PAF-R), other putative ligands for this
receptor have been described including 1-acyl analogs of sn-2 acetyl
glycerophosphocholines. Previous bioassays have demonstrated a PAF-like activity in …
