[HTML][HTML] The cathepsin B inhibitor z-FA. fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide
P Schotte, R Schauvliege, S Janssens… - Journal of Biological …, 2001 - ASBMB
Cathepsin B has previously been shown to proteolytically activate the proinflammatory
caspase-11 in vitro. Here we show that cathepsin B is not involved in activation of caspase-
11 induced by lipopolysaccharide (LPS) and subsequent maturation of interleukin (IL)-1β in
macrophages. Nevertheless, we found that the cathepsin B inhibitor benzyloxycarbonyl-Phe-
Ala-fluoromethylketone (z-FA. fmk) prevents LPS-induced production of IL-1α, IL-1β, and
tumor necrosis factor at the transcriptional level. The latter was not because of cathepsin B …
caspase-11 in vitro. Here we show that cathepsin B is not involved in activation of caspase-
11 induced by lipopolysaccharide (LPS) and subsequent maturation of interleukin (IL)-1β in
macrophages. Nevertheless, we found that the cathepsin B inhibitor benzyloxycarbonyl-Phe-
Ala-fluoromethylketone (z-FA. fmk) prevents LPS-induced production of IL-1α, IL-1β, and
tumor necrosis factor at the transcriptional level. The latter was not because of cathepsin B …
