Apoptosis of Th1-like cells in experimental tuberculosis (TB)
G Das, H Vohra, B Saha, JN Agrewala… - Clinical & …, 1999 - academic.oup.com
G Das, H Vohra, B Saha, JN Agrewala, GC Mishra
Clinical & Experimental Immunology, 1999•academic.oup.comTh1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium
tuberculosis infection in a susceptible host. This study was designed to test the mechanism
of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M.
tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression
in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis
and decreased production of IL-2 and interferon-gamma (IFN-γ) but not of IL-4. These …
tuberculosis infection in a susceptible host. This study was designed to test the mechanism
of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M.
tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression
in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis
and decreased production of IL-2 and interferon-gamma (IFN-γ) but not of IL-4. These …
Summary
Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma (IFN-γ) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.
Oxford University Press