The ability of glucocorticoids (GCs) to regulate cell proliferation plays an important role in
their therapeutic use. The canonical Wnt pathway, which promotes the proliferation of many
cancers and differentiated tissues, is an emerging target for the actions of GCs, albeit
existing links between these signaling pathways are indirect. By screening known Wnt target
genes for their ability to respond differently to GCs in cells whose proliferation is either
positively or negatively regulated by GCs, we identified c-myc, c-jun, and cyclin D1, which …