Synergy between encephalitogenic T cells and myelin basic protein-specific antibodies in the induction of experimental autoimmune encephalomyelitis
KJ Myers, J Sprent, JP Dougherty, Y Ron - Journal of neuroimmunology, 1992 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is an experimentally induced
demyelinating disease mediated by CD4+ T cells specific for various myelin proteins
including myelin basic protein (MBP) and myelin proteolipid protein (PLP). Although myelin-
and other CNS-specific antibodies are produced in EAE, B cells and antibodies are thought
by most not to play a decisive role in the induction of EAE. In this report we show that B cells
serve as the major antigen-presenting cells (APC) during the T cell activation stage in lymph …
demyelinating disease mediated by CD4+ T cells specific for various myelin proteins
including myelin basic protein (MBP) and myelin proteolipid protein (PLP). Although myelin-
and other CNS-specific antibodies are produced in EAE, B cells and antibodies are thought
by most not to play a decisive role in the induction of EAE. In this report we show that B cells
serve as the major antigen-presenting cells (APC) during the T cell activation stage in lymph …
