[HTML][HTML] Regulatory T cells
BR Blazar, PA Taylor - Biology of Blood and Marrow Transplantation, 2005 - astctjournal.org
A subpopulation of naive CD4+ T cells that coexpresses the interleukin (IL)–2 receptor α
chain, CD25, has been shown to have potent suppressor activity [1-12]. Although they are
present in both rodents and humans, the frequencies of CD4+ CD25bright cells are higher in
rodents than in humans (8%-12% versus 1%-3%, respectively, of CD4+ T cells). CD4+
CD25+ cells have been shown to play a vital role in the induction and maintenance of
peripheral self-tolerance by preventing the proliferation and activation of autoreactive T cells …
chain, CD25, has been shown to have potent suppressor activity [1-12]. Although they are
present in both rodents and humans, the frequencies of CD4+ CD25bright cells are higher in
rodents than in humans (8%-12% versus 1%-3%, respectively, of CD4+ T cells). CD4+
CD25+ cells have been shown to play a vital role in the induction and maintenance of
peripheral self-tolerance by preventing the proliferation and activation of autoreactive T cells …
