Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells
A Papi, NG Papadopoulos, LA Stanciu, K Degitz… - Journal of allergy and …, 2001 - Elsevier
Background: Rhinoviruses have been recently associated with the majority of asthma
exacerbations for which current therapy is inadequate. Intercellular adhesion molecule 1
(ICAM-1) has a central role in airway inflammation in asthma, and it is the receptor for 90%
of rhinoviruses. Rhinovirus infection of airway epithelium induces ICAM-1. Desloratadine
and loratadine are compounds belonging to the new class of H1-receptor blockers. Anti-
inflammatory properties of antihistamines have been recently documented, although the …
exacerbations for which current therapy is inadequate. Intercellular adhesion molecule 1
(ICAM-1) has a central role in airway inflammation in asthma, and it is the receptor for 90%
of rhinoviruses. Rhinovirus infection of airway epithelium induces ICAM-1. Desloratadine
and loratadine are compounds belonging to the new class of H1-receptor blockers. Anti-
inflammatory properties of antihistamines have been recently documented, although the …
