Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness
EW Gelfand, ZH Cui, K Takeda, A Kanehiro… - Journal of allergy and …, 2002 - Elsevier
Background: Antihistamines have been evaluated for usefulness in the treatment of asthma
for more than 50 years. Interest was limited until the introduction of newer compounds that
were free of much of the dose-limiting sedation associated with the earlier drugs. Objective:
In a murine model of allergen-induced airway inflammation and hyperresponsiveness, the
efficacy of an H1 receptor antagonist to prevent allergic inflammation and altered airway
function was evaluated. Methods: Mice were sensitized and challenged to an allergen …
for more than 50 years. Interest was limited until the introduction of newer compounds that
were free of much of the dose-limiting sedation associated with the earlier drugs. Objective:
In a murine model of allergen-induced airway inflammation and hyperresponsiveness, the
efficacy of an H1 receptor antagonist to prevent allergic inflammation and altered airway
function was evaluated. Methods: Mice were sensitized and challenged to an allergen …
