Cetirizine inhibits the in vitro and ex vivo chemotactic response of T lymphocytes and monocytes
T Jinquan, CM Reimert, B Deleuran… - Journal of allergy and …, 1995 - Elsevier
We have studied the effect of a nonsedating antihistamine, cetirizine dihydrochloride, on the
in vitro chemotaxis of leukocytes from human peripheral blood. We observed that 0.25 μg/ml
of cetirizine dihydrochloride in vitro significantly inhibited the chemotaxis of monocytes
toward N-formyl-methionyl-leucyl-phenylalanine and leukotriene B4. Higher concentrations
of cetirizine, 1.0 and 2.5 μg/ml, completely inhibited monocyte chemotaxis without affecting
cell viability. T-lymphocyte migration was also significantly depressed but not abolished …
in vitro chemotaxis of leukocytes from human peripheral blood. We observed that 0.25 μg/ml
of cetirizine dihydrochloride in vitro significantly inhibited the chemotaxis of monocytes
toward N-formyl-methionyl-leucyl-phenylalanine and leukotriene B4. Higher concentrations
of cetirizine, 1.0 and 2.5 μg/ml, completely inhibited monocyte chemotaxis without affecting
cell viability. T-lymphocyte migration was also significantly depressed but not abolished …
