Regulation of mature T cell homeostasis
CD Surh, J Sprent - Seminars in immunology, 2005 - Elsevier
CD Surh, J Sprent
Seminars in immunology, 2005•ElsevierThe overall size and the composition of the mature T cell pool are regulated by homeostatic
mechanisms. Recent work has revealed that homeostatic signals are received from contact
with two members of the common gamma chain family of cytokines, IL-7 and IL-15, and from
self-MHC/peptide ligands. In essence, homeostasis of naïve T cells is regulated by IL-7 and
self-MHC/peptide ligands and homeostasis of memory CD8 cells is controlled by IL-7 and IL-
15. All of these signals also appear to be important to a varying degree for homeostasis of …
mechanisms. Recent work has revealed that homeostatic signals are received from contact
with two members of the common gamma chain family of cytokines, IL-7 and IL-15, and from
self-MHC/peptide ligands. In essence, homeostasis of naïve T cells is regulated by IL-7 and
self-MHC/peptide ligands and homeostasis of memory CD8 cells is controlled by IL-7 and IL-
15. All of these signals also appear to be important to a varying degree for homeostasis of …
The overall size and the composition of the mature T cell pool are regulated by homeostatic mechanisms. Recent work has revealed that homeostatic signals are received from contact with two members of the common gamma chain family of cytokines, IL-7 and IL-15, and from self-MHC/peptide ligands. In essence, homeostasis of naïve T cells is regulated by IL-7 and self-MHC/peptide ligands and homeostasis of memory CD8 cells is controlled by IL-7 and IL-15. All of these signals also appear to be important to a varying degree for homeostasis of memory CD4 cells, but the details are less well understood than for other cell type.
Elsevier
