Blocking IL-1 in systemic inflammation
CA Dinarello - The Journal of experimental medicine, 2005 - rupress.org
CA Dinarello
The Journal of experimental medicine, 2005•rupress.orgA growing number of systemic inflammatory diseases characterized in part by recurrent
fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-
1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1
receptors. Rapid resolution of systemic and local inflammation is now also reported in
systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1β
might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.
fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-
1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1
receptors. Rapid resolution of systemic and local inflammation is now also reported in
systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1β
might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.
A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1β might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.
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