[HTML][HTML] Suppressor of cytokine signaling 3 regulates proliferation and activation of T-helper cells
CR Yu, RM Mahdi, S Ebong, BP Vistica, I Gery… - Journal of Biological …, 2003 - ASBMB
Suppressors of cytokine signaling (SOCS) have been implicated in regulation of T-cell
activation and cytokine-mediated differentiation of T-helper cells. In this study we have
characterized the pattern of SOCS expression in naïve and activated primary T-helper
cells, examined whether expression of SOCS genes is regulated by cytokine or T-cell
receptor signaling, and analyzed the function of SOCS in differentiated T-cells. We show that
SOCS1, SOCS2, SOCS3, CIS (cytokine-induced SH2 protein) genes are constitutively …
activation and cytokine-mediated differentiation of T-helper cells. In this study we have
characterized the pattern of SOCS expression in naïve and activated primary T-helper
cells, examined whether expression of SOCS genes is regulated by cytokine or T-cell
receptor signaling, and analyzed the function of SOCS in differentiated T-cells. We show that
SOCS1, SOCS2, SOCS3, CIS (cytokine-induced SH2 protein) genes are constitutively …
