[HTML][HTML] Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1β on the growth hormone-dependent transcription of the acid …
YR Boisclair, J Wang, J Shi, KR Hurst, GT Ooi - Journal of Biological …, 2000 - ASBMB
During catabolic diseases such as sepsis, inflammation, and infection, a state of growth
hormone (GH) resistance develops in liver. This has been attributed in part to increased
production of the proinflammatory cytokine interleukin-1β (IL-1β). To determine how IL-1β
induces GH resistance, we studied the acid-labile subunit (ALS) gene whose hepatic
transcription is increased by GH via the Janus kinase-signal transducer and activator of
transcription (JAK-STAT) pathway. IL-1β reduced the ability of GH to stimulate ALS mRNA in …
hormone (GH) resistance develops in liver. This has been attributed in part to increased
production of the proinflammatory cytokine interleukin-1β (IL-1β). To determine how IL-1β
induces GH resistance, we studied the acid-labile subunit (ALS) gene whose hepatic
transcription is increased by GH via the Janus kinase-signal transducer and activator of
transcription (JAK-STAT) pathway. IL-1β reduced the ability of GH to stimulate ALS mRNA in …
