Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2
BJ Pettus, A Bielawska, P Subramanian… - Journal of Biological …, 2004 - ASBMB
Recently, we demonstrated that ceramide kinase, and its product, ceramide 1-phosphate
(Cer-1-P), were mediators of arachidonic acid released in cells in response to interleukin-1β
and calcium ionophore (Pettus, BJ, Bielawska, A., Spiegel, S., Roddy, P., Hannun, YA, and
Chalfant, CE (2003) J. Biol. Chem. 278, 38206–38213). In this study, we demonstrate that
down-regulation of cytosolic phospholipase A 2 (cPLA 2) using RNA interference technology
abolished the ability of Cer-1-P to induce arachidonic acid release in A549 cells …
(Cer-1-P), were mediators of arachidonic acid released in cells in response to interleukin-1β
and calcium ionophore (Pettus, BJ, Bielawska, A., Spiegel, S., Roddy, P., Hannun, YA, and
Chalfant, CE (2003) J. Biol. Chem. 278, 38206–38213). In this study, we demonstrate that
down-regulation of cytosolic phospholipase A 2 (cPLA 2) using RNA interference technology
abolished the ability of Cer-1-P to induce arachidonic acid release in A549 cells …
