[HTML][HTML] Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP)
AJ Petrolonis, Q Yang, PJ Tummino, SM Fish… - Journal of Biological …, 2004 - ASBMB
Glucose is the main physiological stimulus for insulin biosynthesis and secretion by
pancreatic β-cells. Glucose-6-phosphatase (G-6-Pase) catalyzes the dephosphorylation of
glucose-6-phosphate to glucose, an opposite process to glucose utilization. G-6-Pase
activity in pancreatic islets could therefore be an important factor in the control of glucose
metabolism and, consequently, of glucose-dependent insulin secretion. While G-6-Pase
activity has been shown to be present in pancreatic islets, the gene responsible for this …
pancreatic β-cells. Glucose-6-phosphatase (G-6-Pase) catalyzes the dephosphorylation of
glucose-6-phosphate to glucose, an opposite process to glucose utilization. G-6-Pase
activity in pancreatic islets could therefore be an important factor in the control of glucose
metabolism and, consequently, of glucose-dependent insulin secretion. While G-6-Pase
activity has been shown to be present in pancreatic islets, the gene responsible for this …
