Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury
C Lang, Y Meier, B Stieger, U Beuers… - Pharmacogenetics …, 2007 - journals.lww.com
Objectives Increasing evidence suggests that a genetically determined functional
impairment of the hepatocellular efflux transporters bile salt export pump (BSEP, ABCB11)
and multidrug resistance protein 3 (MDR3, ABCB4) play a pathophysiological role in the
development of drug-induced liver injury. The aim of this study was therefore to describe the
extent of genetic variability in ABCB11 and ABCB4 in patients with drug-induced liver injury
and to in vitro functionally characterize newly detected ABCB11 mutations and …
impairment of the hepatocellular efflux transporters bile salt export pump (BSEP, ABCB11)
and multidrug resistance protein 3 (MDR3, ABCB4) play a pathophysiological role in the
development of drug-induced liver injury. The aim of this study was therefore to describe the
extent of genetic variability in ABCB11 and ABCB4 in patients with drug-induced liver injury
and to in vitro functionally characterize newly detected ABCB11 mutations and …
