Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis
W Denham, J Yang, G Fink, D Denham, G Carter… - …, 1997 - gastrojournal.org
BACKGROUND & AIMS: During severe pancreatitis, interleukin (IL)-1beta and tumor
necrosis factor (TNF)-alpha are produced in large quantities. The aim of this study was to
determine whether either one plays a more dominant role and if their detrimental effects are
additive. METHODS: Necrotizing pancreatitis was induced in transgenic (-/-) knockout mice
deficient in either IL-1 type 1 receptors, TNF type 1 receptors, or both IL-1 and TNF type 1
receptors. Wild-type mice served as controls. Mortality was assessed for 10 days. Additional …
necrosis factor (TNF)-alpha are produced in large quantities. The aim of this study was to
determine whether either one plays a more dominant role and if their detrimental effects are
additive. METHODS: Necrotizing pancreatitis was induced in transgenic (-/-) knockout mice
deficient in either IL-1 type 1 receptors, TNF type 1 receptors, or both IL-1 and TNF type 1
receptors. Wild-type mice served as controls. Mortality was assessed for 10 days. Additional …
