Rocaglamide derivatives are potent inhibitors of NF-κB activation in T-cells
B Baumann, F Bohnenstengel, D Siegmund… - Journal of Biological …, 2002 - ASBMB
Crude extracts from different Aglaiaspecies are used as anti-inflammatory remedies in the
traditional medicine of several countries from Southeast Asia. Because NF-κB transcription
factors represent key regulators of genes involved in immune and inflammatory responses,
we supposed that the anti-inflammatory effects of Aglaia extracts are mediated by the
inhibition of NF-κB activity. Purified compounds ofAglaia species, namely 1H-cyclopenta [b]
benzofuran lignans of the rocaglamide type as well as one aglain congener were tested for …
traditional medicine of several countries from Southeast Asia. Because NF-κB transcription
factors represent key regulators of genes involved in immune and inflammatory responses,
we supposed that the anti-inflammatory effects of Aglaia extracts are mediated by the
inhibition of NF-κB activity. Purified compounds ofAglaia species, namely 1H-cyclopenta [b]
benzofuran lignans of the rocaglamide type as well as one aglain congener were tested for …
