Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and-2) in mice
JI Mobarakeh, K Takahashi, S Sakurada, S Nishino… - Peptides, 2005 - Elsevier
Orexins are neuropeptides located exclusively in neurons of the lateral hypothalamic area,
which send projections to most monoaminergic nuclei, such as noradrenergic locus
coeruleus, dopaminergic ventral tegmental areas, and histaminergic tuberomammillary
nuclei. The present work was carried out to examine the role of orexins in nociception in
mice. C57BL/6 mice were administered with orexin A and B intracerebroventricularly (icv),
intrathecally (it) and subcutaneously (sc) to reveal the sites of action of these peptides and to …
which send projections to most monoaminergic nuclei, such as noradrenergic locus
coeruleus, dopaminergic ventral tegmental areas, and histaminergic tuberomammillary
nuclei. The present work was carried out to examine the role of orexins in nociception in
mice. C57BL/6 mice were administered with orexin A and B intracerebroventricularly (icv),
intrathecally (it) and subcutaneously (sc) to reveal the sites of action of these peptides and to …
