Orexin-A, an hypothalamic peptide with analgesic properties
S Bingham, PT Davey, AJ Babbs, EA Irving… - Pain, 2001 - Elsevier
The hypothalamic peptide orexin-A and the orexin-1 receptor are localized in areas of the
brain and spinal cord associated with nociceptive processing. In the present study,
localization was confirmed in the spinal cord and demonstrated in the dorsal root ganglion
for both orexin-A and the orexin-1 receptor. The link with nociception was extended when
orexin-A was shown to be analgesic when given iv but not sc in mouse and rat models of
nociception and hyperalgesia. The efficacy of orexin-A was similar to that of morphine in the …
brain and spinal cord associated with nociceptive processing. In the present study,
localization was confirmed in the spinal cord and demonstrated in the dorsal root ganglion
for both orexin-A and the orexin-1 receptor. The link with nociception was extended when
orexin-A was shown to be analgesic when given iv but not sc in mouse and rat models of
nociception and hyperalgesia. The efficacy of orexin-A was similar to that of morphine in the …
