Introduction: The HERG channel is widely used for the assessment of proarrhythmic risk for
new drugs. HERG channel blockers obstruct channel functions through various
mechanisms, which usually show time dependence, voltage dependence, and state
dependence. The voltage protocol and temperature may affect the estimation of drug
potency, but limited information is available in this regard. The purpose of this study was to
evaluate the influence of voltage protocol and temperature on predicting the potency of …