[HTML][HTML] Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease
Y Maeda, I Tawara, T Teshima, C Liu… - Experimental …, 2007 - Elsevier
OBJECTIVE: T cells that undergo lymphopenia-induced proliferation (LIP) are characterized
by greater effector and anti-tumor function than naïve T cells. But the ability of these T cells in
causing graft-versus-host disease (GVHD) is not known. METHODS: We tested the
hypothesis that donor T cells that had undergone LIP would cause more severe GVHD than
naïve T cells by utilizing well-characterized murine experimental models of allogeneic bone
marrow transplantation (BMT). RESULTS: Contrary to our hypothesis, LIP of donor T cells …
by greater effector and anti-tumor function than naïve T cells. But the ability of these T cells in
causing graft-versus-host disease (GVHD) is not known. METHODS: We tested the
hypothesis that donor T cells that had undergone LIP would cause more severe GVHD than
naïve T cells by utilizing well-characterized murine experimental models of allogeneic bone
marrow transplantation (BMT). RESULTS: Contrary to our hypothesis, LIP of donor T cells …
