[HTML][HTML] Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions
I Viard-Leveugle, RR Bullani, P Meda… - Journal of Biological …, 2003 - ASBMB
Acquired Fas ligand (FasL)-mediated cytolytic activity of human keratinocytes causes the
massive keratinocyte cell death that occurs during toxic epidermal necrolysis, a deadly
adverse drug eruption. Under normal conditions keratinocyte apoptosis is a rare event in the
epidermis although keratinocytes express the death receptor Fas and its ligand. Here we
have investigated why this is so. We show that Fas, FasL, Fas-associated death domain, and
caspase-8 mRNA are detectable in the epidermis, primary keratinocyte cultures, and …
massive keratinocyte cell death that occurs during toxic epidermal necrolysis, a deadly
adverse drug eruption. Under normal conditions keratinocyte apoptosis is a rare event in the
epidermis although keratinocytes express the death receptor Fas and its ligand. Here we
have investigated why this is so. We show that Fas, FasL, Fas-associated death domain, and
caspase-8 mRNA are detectable in the epidermis, primary keratinocyte cultures, and …