[HTML][HTML] Regulation of nucleocytoplasmic trafficking of transcription factor OREBP/TonEBP/NFAT5
EHY Tong, JJ Guo, AL Huang, H Liu, CD Hu… - Journal of biological …, 2006 - ASBMB
The osmotic response element-binding protein (OREBP), also known as tonicity enhancer-
binding protein (TonEBP) or NFAT5, regulates the hypertonicity-induced expression of a
battery of genes crucial for the adaptation of mammalian cells to extracellular hypertonic
stress. The activity of OREBP/TonEBP is regulated at multiple levels, including
nucleocytoplasmic trafficking. OREBP/TonEBP protein can be detected in both the
cytoplasm and nucleus under isotonic conditions, although it accumulates exclusively in the …
binding protein (TonEBP) or NFAT5, regulates the hypertonicity-induced expression of a
battery of genes crucial for the adaptation of mammalian cells to extracellular hypertonic
stress. The activity of OREBP/TonEBP is regulated at multiple levels, including
nucleocytoplasmic trafficking. OREBP/TonEBP protein can be detected in both the
cytoplasm and nucleus under isotonic conditions, although it accumulates exclusively in the …