Mφ1 and Mφ2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals
A Gratchev, J Kzhyshkowska, K Köthe, I Muller-Molinet… - Immunobiology, 2006 - Elsevier
Macrophages (Mφ) represent a dynamic cell population that develops and operates within a
changing microenvironment. In parallel to Th1/Th2 cells, primary Mφ may undergo classical
(Mφ1) or alternative (Mφ2) activation. Here, we investigated whether Mφ1/Mφ2 may be re-
polarized by a secondary stimulation by Th1 or Th2 cytokines or by exogenous danger
signals. We established that Mφ1IFNγ respond to alternative activation by IL-4 and IL-10 by
de novo secretion of Th2 cytokines AMAC-1 and IL-1ra, and by an increase in phagocytic …
changing microenvironment. In parallel to Th1/Th2 cells, primary Mφ may undergo classical
(Mφ1) or alternative (Mφ2) activation. Here, we investigated whether Mφ1/Mφ2 may be re-
polarized by a secondary stimulation by Th1 or Th2 cytokines or by exogenous danger
signals. We established that Mφ1IFNγ respond to alternative activation by IL-4 and IL-10 by
de novo secretion of Th2 cytokines AMAC-1 and IL-1ra, and by an increase in phagocytic …