[HTML][HTML] Paclitaxel-induced apoptosis in Jurkat, a leukemic T cell line, is enhanced by ceramide
D Myrick, D Blackinton, J Klostergaard, N Kouttab… - Leukemia research, 1999 - Elsevier
We hypothesized that the lipid second messenger, ceramide, and microtubule-directed
chemotherapeutic agents might engage converging pathways in inducing apoptosis. Our
studies demonstrated that simultaneous treatment of Jurkat cells with paclitaxel and
ceramide enhanced paclitaxel-induced cell growth inhibition. Cell cycle analysis indicated a
significant increase in the hypodiploid population over that observed with paclitaxel
treatment alone. Morphologic evaluation and a TUNEL assay confirmed a dramatic increase …
chemotherapeutic agents might engage converging pathways in inducing apoptosis. Our
studies demonstrated that simultaneous treatment of Jurkat cells with paclitaxel and
ceramide enhanced paclitaxel-induced cell growth inhibition. Cell cycle analysis indicated a
significant increase in the hypodiploid population over that observed with paclitaxel
treatment alone. Morphologic evaluation and a TUNEL assay confirmed a dramatic increase …