[HTML][HTML] Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of β-defensins during Helicobacter pylori infection
PK Boughan, RH Argent, M Body-Malapel… - Journal of Biological …, 2006 - ASBMB
Host-pathogen interactions that allow Helicobacter pylori to survive and persist in the
stomach of susceptible individuals remain unclear. Human β-defensins (hBDs), epithelial-
derived antimicrobial peptides are critical components of host-defense at mucosal surfaces.
The role of H. pylori-mediated NF-κB and epidermal growth factor receptor (EGFR) activation
on β-defensin expression was investigated. Transient transfection studies utilizing β-
defensin promoter constructs were conducted in gastric cells with contribution of individual …
stomach of susceptible individuals remain unclear. Human β-defensins (hBDs), epithelial-
derived antimicrobial peptides are critical components of host-defense at mucosal surfaces.
The role of H. pylori-mediated NF-κB and epidermal growth factor receptor (EGFR) activation
on β-defensin expression was investigated. Transient transfection studies utilizing β-
defensin promoter constructs were conducted in gastric cells with contribution of individual …
