Leukocidin from Staphylococcus aureus and cutaneous infections: an epidemiologic study
P Couppie, B Cribier, G Prévost… - Archives of …, 1994 - jamanetwork.com
Panton-Valentine leukocidin (PVL) is a cytotoxin produced by less than 5%
ofStaphylococcus aureusstrains, which act only on human and rabbit polymorphonuclear
cells (PMNs) and monocytes but not on erythrocytes. 1, 2 Injections of purified PVL into
rabbit skin were shown to induce karyorrhexis of PMNs and vascular necrosis, which led to a
large ulceration. 3 To more clearly assess the relationships between PVL production and
human pathology, we report a prospective epidemiologic study of 302 Saureusstrains …
ofStaphylococcus aureusstrains, which act only on human and rabbit polymorphonuclear
cells (PMNs) and monocytes but not on erythrocytes. 1, 2 Injections of purified PVL into
rabbit skin were shown to induce karyorrhexis of PMNs and vascular necrosis, which led to a
large ulceration. 3 To more clearly assess the relationships between PVL production and
human pathology, we report a prospective epidemiologic study of 302 Saureusstrains …