Role of Streptococcus pyogenes Two-Component Response Regulators in the Temporal Control of Mga and the Mga-Regulated Virulence Gene emm
DA Ribardo, TJ Lambert, KS McIver - Infection and immunity, 2004 - Am Soc Microbiol
DA Ribardo, TJ Lambert, KS McIver
Infection and immunity, 2004•Am Soc MicrobiolWe examined the role of Streptococcus pyogenes two-component response regulators
(SptR) in expression of Mga and the Mga-regulated gene emm. Both serotype M6 and
serotype M1 mutants in 12 of the 13 identified sptR genes exhibited levels of emm
transcripts and Mga protein comparable to those of the wild type during exponential and
stationary phases of growth. Thus, temporal control of these virulence genes does not
require Spt response regulators.
(SptR) in expression of Mga and the Mga-regulated gene emm. Both serotype M6 and
serotype M1 mutants in 12 of the 13 identified sptR genes exhibited levels of emm
transcripts and Mga protein comparable to those of the wild type during exponential and
stationary phases of growth. Thus, temporal control of these virulence genes does not
require Spt response regulators.
Abstract
We examined the role of Streptococcus pyogenes two-component response regulators (SptR) in expression of Mga and the Mga-regulated gene emm. Both serotype M6 and serotype M1 mutants in 12 of the 13 identified sptR genes exhibited levels of emm transcripts and Mga protein comparable to those of the wild type during exponential and stationary phases of growth. Thus, temporal control of these virulence genes does not require Spt response regulators.
American Society for Microbiology