Orchestration of coagulation protease signaling by tissue factor
M Riewald, W Ruf - Trends in cardiovascular medicine, 2002 - Elsevier
Protease-activated receptors (PARs) are vascular sensors for signaling of the trypsinlike
coagulation serine proteases that play key roles in cardiovascular medicine. In the initiation
phase of coagulation, tissue factor (TF) orchestrates the assembly of VIIa with substrate X,
forming a ternary complex in which product Xa is generated. The resulting TF–VIIa–Xa
complex is an efficient activator of PAR1 and PAR2. TF initiation of the coagulation cascade
is thus intimately linked to inflammatory cell signaling. Inflammation is an increasingly …
coagulation serine proteases that play key roles in cardiovascular medicine. In the initiation
phase of coagulation, tissue factor (TF) orchestrates the assembly of VIIa with substrate X,
forming a ternary complex in which product Xa is generated. The resulting TF–VIIa–Xa
complex is an efficient activator of PAR1 and PAR2. TF initiation of the coagulation cascade
is thus intimately linked to inflammatory cell signaling. Inflammation is an increasingly …