Distribution of 1, 2 DMH-induced colonic aberrant crypt foci after administration of a gastrin receptor antagonist (CR2945), in the murine model
MG Fontana, M Ghirardi… - Annali Italiani di …, 2001 - annaliitalianidichirurgia.it
MG Fontana, M Ghirardi, D Moneghini, M La Pinta, B Salerni, V Villanacci, F Donato
Annali Italiani di Chirurgia, 2001•annaliitalianidichirurgia.itDistribution of 1,2 DMH-induced colonic aberrant crypt foci after administration of a gastrin
receptor antagonist (CR2945), in t Page 1 Introduction A possible role of gastrin in the
development of colorectal cancer has been proposed years ago, when some reports showed
that gastrin stimulates the growth of epithelial cultures derived from gastric and intestinal
mucosa and enhances cancer growth in rodents as well as in culture (13, 14, 15, 7, 32, 25, 37,
12, 33). Gastrin receptors have been located on normal and neoplastic gastric and colonic …
receptor antagonist (CR2945), in t Page 1 Introduction A possible role of gastrin in the
development of colorectal cancer has been proposed years ago, when some reports showed
that gastrin stimulates the growth of epithelial cultures derived from gastric and intestinal
mucosa and enhances cancer growth in rodents as well as in culture (13, 14, 15, 7, 32, 25, 37,
12, 33). Gastrin receptors have been located on normal and neoplastic gastric and colonic …
Abstract
Our previous experimental data demonstrated that a new gastrin receptor antagonist (CR2945) has a chemopreventive effect on dimethylhydrazine-induced colon cancer in mice.
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