[HTML][HTML] Busulfan-conditioned bone marrow transplantation results in high-level allogeneic chimerism in mice made tolerant by in utero hematopoietic cell …
S Ashizuka, WH Peranteau, S Hayashi… - Experimental hematology, 2006 - Elsevier
OBJECTIVE: In utero hematopoietic cell transplantation (IUHCT) is a nonablative approach
that achieves mixed allogeneic chimerism and donor-specific tolerance. However, clinical
application of IUHCT has been limited by minimal engraftment. We have previously
demonstrated in the murine model that low-level allogeneic chimerism achieved by IUHCT
can be enhanced to near-complete donor chimerism by postnatal minimally myeloablative
total body irradiation (TBI) followed by same-donor bone marrow transplantation. Because of …
that achieves mixed allogeneic chimerism and donor-specific tolerance. However, clinical
application of IUHCT has been limited by minimal engraftment. We have previously
demonstrated in the murine model that low-level allogeneic chimerism achieved by IUHCT
can be enhanced to near-complete donor chimerism by postnatal minimally myeloablative
total body irradiation (TBI) followed by same-donor bone marrow transplantation. Because of …
