[HTML][HTML] Prion protein protects human neurons against Bax-mediated apoptosis
Y Bounhar, Y Zhang, CG Goodyer, A LeBlanc - Journal of Biological …, 2001 - ASBMB
The function of the cellular prion protein (PrP) is still poorly understood. We present here an
unprecedented role for PrP against Bax-mediated neuronal apoptosis and show that PrP
potently inhibits Bax-induced cell death in human primary neurons. Deletion of four
octapeptide repeats of PrP (PrPΔOR) and familial D178N and T183A PrP mutations
completely or partially eliminate the neuroprotective effect of PrP. PrP remains anti-apoptotic
despite truncation of the glycosylphosphatidylinositol (GPI) anchor signal peptide, indicating …
unprecedented role for PrP against Bax-mediated neuronal apoptosis and show that PrP
potently inhibits Bax-induced cell death in human primary neurons. Deletion of four
octapeptide repeats of PrP (PrPΔOR) and familial D178N and T183A PrP mutations
completely or partially eliminate the neuroprotective effect of PrP. PrP remains anti-apoptotic
despite truncation of the glycosylphosphatidylinositol (GPI) anchor signal peptide, indicating …
