The limited regenerative capacity of the glomerular podocyte following injury underlies the
development of glomerulosclerosis and progressive renal failure in a diverse range of
kidney diseases. We discovered that, in the kidney, cyclin I is uniquely expressed in the
glomerular podocyte, and have constructed cyclin I knock-out mice to explore the biological
function of cyclin I in these cells. Cyclin I knock-out (–/–) podocytes showed an increased
susceptibility to apoptosis both in vitro and in vivo. Following induction of experimental …